Primary Localized Cutaneous Amyloidosis (PLCA) is a condition characterized by the deposition of amyloid protein plaques in the dermal layer of the skin, without any evidence of such deposits in the internal organs. Three major types of PLCAs are recognized- Lichen, Macular and Nodular PLCA, with the macular form being the most common. The condition is caused by mutations in the OSMR gene, which encodes a receptor for the cytokine Oncostatin M.