WFS2 is the second gene locus found to be associated with Wolfram Syndrome. Patients affected with Wolfram Syndrome 2 present with the classical symptoms of diabetes mellitus, optic atrophy, and sensorineural hearing loss, but do not show any evidence of diabetes insipidus, the other main feature of classical Wolfram Syndrome. In addition, these patients also present with peptic ulcer disease, a significant bleeding tendency brought about by defective platelet aggregation and various neurological symptoms.