Sebetan et al. (1997) carried out a study to investigate the genetic variants of the human plasma orosomucoid ORM1 and ORM2 gene loci in Egyptians. In this study, 271 plasma samples from unrelated healthy blood donors were collected and used within a few days of collection. Isoelectric focusing was used for phenotyping all samples. Also, Sebetan et al. (1997) studied the ORM2 locus in the Qatari and Sudanese populations. In the three populations, the ORM2 locus showed one common and nine variants phenotypes that are determined by nine ORM2 alleles: ORM2*M, ORM2*L4, ORM2*H2, ORM2*H10, ORM2*H13, ORM2*H14, ORM2*Q0, a new allele designated ORM2*H21, and a double-banded allele that is renamed ORM2*HX. Family studies of the new allele (ORM*H21) are in accordance with co-dominant autosomal inheritance. Sebetan et al. (1997) found five ORM1 alleles in Egyptians which are in decreasing order: ORM2*M, ORM2*H2, ORM2*H13, ORM2*H14, and ORM2*HX. The most common phenotype found in Egyptians is the M phenotype of the ORM2 combined with the ORM1 phenotypes. Out of the 271 subjects analyzed, 119 had the M phenotype of the ORM2 combined with F1.S phenotype (determined by two ORM1 (F1/S and dF1S/dF1S) genotypes) of the ORM1. The M phenotype combined with the F1 and S phenotypes of the ORM1 was found in 90 and 35 Egyptians, respectively.

Sebetan and Sagisaka (1988) characterized the genetic polymorphisms of orosomucoid ORM2 and ORM2 in Libyans and indicated the occurrence of three new ORM2 alleles. No further details could be obtained on this subject.

Sebetan et al. (1997) carried out a study to investigate the genetic variants of the human plasma orosomucoid ORM1 and ORM2 gene loci in Qataris. In this study, 400 plasma samples from unrelated healthy blood donors were collected and used within a few days of collection. Sebetan et al. (1997) found four ORM2 alleles in Qataris which are in decreasing order: ORM2*M, ORM2*L4, ORM2*H10, and ORM2*H21. The most common phenotype in Qataris is the M phenotype of the ORM2 combined with the ORM1 phenotypes. Out of the 400 subjects analyzed, 177 had the M phenotype of the ORM2 combined with F1.S phenotype (determined by two ORM1 (F1/S and dF1S/dF1S) genotypes) of the ORM1. The M phenotype combined with the F1 and S phenotypes of the ORM1 was found in 193 and 59 Qataris, respectively [See also: Egypt > Sebetan et al., 1997].

Sebetan et al. (1997) carried out a study to investigate the genetic variants of the human plasma orosomucoid ORM1 and ORM2 gene loci in Sudanese. In this study, 195 plasma samples from unrelated healthy blood donors were collected and used within a few days of collection. Sebetan et al. (1997) found four ORM2 alleles in Sudanese people that are in decreasing order: ORM2*M, ORM2*H2, ORM2*H21, and ORM2*HX. The most common phenotype found in Sudanese people is the M phenotype of the ORM2 combined with the ORM1 phenotypes. Out of the 195 subjects analyzed, 82 had the M phenotype of the ORM2 combined with F1.S phenotype (determined by two ORM1 (F1/S and dF1S/dF1S) genotypes) of the ORM1. The M phenotype combined with the F1 and S phenotypes of the ORM1 was found in 55 and 72 Sudanese, respectively [See also: Egypt > Sebetan et al., 1997].