Transcription Factor 7-Like 2

Alternative Names

  • TCF7L2
  • T-Cell Transcription Factor 4
  • TCF4
Back to search Result
OMIM Number

602228

NCBI Gene ID

6934

Uniprot ID

Q9NQB0

Length

217,460 bases

No. of Exons

20

No. of isoforms

17

Protein Name

Transcription factor 7-like 2

Molecular Mass

67,919 Da

Amino Acid Count

619

Genomic Location

chr10:112,950,219-113,167,678

Gene Map Locus
10q25.2-q25.3

Description

TCF7L2 gene encodes a transcription factor involved in the Wnt signaling pathway and glucose homeostasis. Single nucleotide polymorphisms in this gene are associated with type 2 diabetes (T2D). In addition, at least one frameshift mutation in the gene has been linked to colon cancer.

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_001146274.1:c.450+29688T>CLebanonNC_000010.11:g.112994312T>CAssociationType 2 Diabetes MellitusNG_012631.1:g.49063T>C; NM_001146274.1:c.450+29688T>C34872471
NM_001146274.1:c.450+29705T>CLebanonNC_000010.11:g.112994329T>CAssociationType 2 Diabetes MellitusNG_012631.1:g.49080T>C; NM_001146274.1:c.450+29705T>C7901695
NM_001146274.1:c.450+30401T>CLebanonNC_000010.11:g.112995025T>CAssociationType 2 Diabetes MellitusNG_012631.1:g.49776T>C; NM_001146274.1:c.450+30401T>C35198068
NM_001146274.1:c.450+31658A>TLebanon; United Arab E...NC_000010.11:g.112996282A>TAssociationType 2 Diabetes MellitusNG_012631.1:g.51033A>T; NM_001146274.1:c.450+31658A>T; NP_001139746.1:p.?4506565
NM_001146274.1:c.450+33966C>TLebanon; Tunisia; Unit...NC_000010.11:g.112998590C>TRisk factorAssociation, Likely BenignType 2 Diabetes Mellitus; ObesityNG_012631.1:g.53341C>T; NM_001146274.1:c.450+33966C>T; NP_001139746.1:p.?79031467413
NM_001146274.1:c.451-10969T>CLebanonNC_000010.11:g.113029056T>CAssociationType 2 Diabetes MellitusNG_012631.1:g.83807T>C; NM_001146274.1:c.451-10969T>C12243326
NM_001146274.1:c.552+1640G>ALebanonNC_000010.11:g.113041766G>AType 2 Diabetes MellitusNG_012631.1:g.96517G>A; NM_001146274.1:c.552+1640G>A7895340
NM_001146274.1:c.552+7162G>CLebanonNC_000010.11:g.113047288G>CRisk factorType 2 Diabetes MellitusNG_012631.1:g.102039G>C; NM_001146274.1:c.552+7162G>C111962057415
NM_001146274.1:c.552+8187T>CUnited Arab EmiratesNC_000010.11:g.113048313T>CAssociationType 2 Diabetes Mellitus; ObesityNG_012631.1:g.103064T>C; NM_001146274.1:c.552+8187T>C; NP_001139746.1:p.?10885409
NM_001146274.1:c.552+9017G>TLebanon; United Arab E...NC_000010.11:g.113049143G>TRisk factorAssociation, BenignType 2 Diabetes MellitusNG_012631.1:g.103894G>T; NM_001146274.1:c.552+9017G>T; NP_001139746.1:p.?122553727414

Other Reports

Morocco

Cauchi et al. (2007) investigated the association between the TCF7L2 rs7903146 polymorphism and T2D in Moroccans (406 normoglycemic individuals and 504 T2D subjects) and in white Austrians. The allelic odds ratios (ORs) for T2D were 1.56 and 1.52 in Moroccans and Austrians, respectively. No heterogeneity was found between these two different populations by Woolf test. Later, Cauchi et al. (2008) included this study group into a larger analysis to validate possible markers that could be highly associated with type 2 diabetes (T2D) in other European and non-European populations. The T2D risk increased strongly when risk alleles, including the T2D-associated TCF7L2 rs7903146 SNP, were combined. Cauchi et al. (2008) concluded that TCF7L2, SLC30A8, HHEX, CDKAL1, IGFBP2, and CDKN2A/CDKN2B genes strongly associate with T2D in French individuals, and mostly in populations of Central European descent, but not in Moroccan subjects.

Saudi Arabia

A study by Alsmadi et al. (2008) was set to determine the role of two variants of the TCF7L2 gene in Arabs in the context of type 2 diabetes (T2D); these variants are rs7903146 and rs12255372. The latter variants have been strongly associated with T2D risk in many populations around the world. Saudi T2D patients (522 individuals), and controls (346 individuals) aged over 60, with fasting plasma glucose < 7 mmol/L were included in a case-control association study. The results indicated weak or no association of T2D in Arabs with the abovementioned TCF7L2 variants.

© CAGS 2024. All rights reserved.