Cerebroretinal microangiopathy with calcifications and cysts (CRMCC) is a rare autosomal recessive genetic disorder characterized by a slowly progressing abnormality in retinal vascular permeability and retinal telangiectasia, along with neurological impairment, skeletal defects, movement disorders, epileptic seizures, osteopenia with frequent brain fractures, and postnatal growth failure. The retinal telangiectasia progresses from yellow white raised exudate patches under normal vessels to retinal detachment, cataract, glaucoma, pthisis bulbi, and, ultimately, blindness. Diagnosis of the condition depends upon brain imaging studies, which should show extensive brain calcifications, with a progressive leukoencephalopathy. CRMCC is also known as Coats Plus syndrome, due to its similarity with Coats disease, another disorder characterized by a similar form of retinal telangiectasia, but without the other features of CRMCC.