Microphthalmia, isolated with coloboma 3 is a rare inherited disorder characterized by small eyes (one or both) and eye colobomas. The clinical findings are confined to the eye in this condition. The globe is abnormally small (defined by some as less than 20 mm in length in at least one eye). Incomplete penetrance and variable expression are typical but often the cornea is small and may be cloudy with anterior synechia suggesting that anterior chamber dysgenesis may also be a feature in some cases. Visual acuity depends on the structures involved. It is not uncommon for other ocular abnormalities to occur in association with the malformed globes, such as cataracts, microcornea, sclerocornea and optic nerve dysplasia.