Human hydrocephalus is a disorder of abnormality in CSF flow or resorption, which has been classified in pertinent literature as congenital and acquired. Congenital hydrocephalus can present as an isolated phenomenon which is common; or with associated anomalies affecting other organs, disturbing physiology or presenting as a syndrome.
Game-Friedman-Paradice syndrome is characterized by growth retardation, hydrocephalus with patent aqueduct of Sylvius, micrognathia, hypoplastic multilobed lungs, intestinal malrotation, omphalocele, shortness of lower limbs, bowed tibias, foot deformities, and other defects.
Diagnosis can be made prenatally using ultrasound examination, via which hydrocephaly can be clearly observed as early as the fourteenth week of gestation.
Farag et al. (1993) screened 400 institutionalized mentally retarded (IQ less than 50) patients in Kuwait, of whom three patients were found to be suffering from hydrocephalus with associated malformations.