The NR2E3 gene encodes a retinal nuclear receptor that belongs to a large family of nuclear receptor transcription factors involved in signaling pathways for photoreceptors. NR2E3 localization is limited to the outer nuclear layer of the human retina, and it is involved in retinal cell fate determination. NR2E3 behaves intracellularly as a ligand-dependent transcription factor with discrete domains that function in DNA and ligand binding. The NR2E3 gene is 410 amino acids long and has two alternatively spliced isoforms.