IL2-Inducible T-Cell Kinase

Alternative Names

  • ITK
  • Tyrosine Kinase Expressed mainly in T Cells
  • EMT
  • T-Cell ITK/TSK Tyrosine Kinase, Mouse, Homolog of
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OMIM Number

186973

NCBI Gene ID

3702

Uniprot ID

Q08881

Length

112,253 bases

No. of Exons

18

No. of isoforms

1

Protein Name

Tyrosine-Protein Kinase ITK/TSK

Molecular Mass

71831 Da

Amino Acid Count

620

Genomic Location

chr5:157,180,839-157,255,184

Gene Map Locus
5q33.3

Description

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_005546.4:c.1562C>TIraqNC_000005.10:g.157245928C>TUncertain SignificancePathogenicLymphoproliferative Syndrome 1NG_016276.1:g.70032C>T; NM_005546.4:c.1562C>T; NP_005537.3:p.Pro521Leu7599324711481575
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