Spastic Paraplegia and Evans Syndrome is a condition in which, as the name suggests, Spastic Paraplegia is seen in conjunction with Evans Syndrome. Evans syndrome is a very rare autoimmune disorder characterized by the simultaneous or sequential association of autoimmune hemolytic anemia, in which the body makes antibodies that destroy the red blood cells, platelets and white blood cells. Affected individuals usually experience thrombocytopenia and Coombs' positive hemolytic anemia. Diagnosis of Evans syndrome is based on a complete blood count test showing anemia and thrombocytopenia, associated or not with neutropenia.
Hereditary spastic paraplegia (HSP) is a group of clinically and genetically diverse disorders characterized by lower extremity spasticity and weakness. HSP clinically can be classified as uncomplicated if neurologic impairment is limited to lower extremity spastic weakness, hypertonic urinary bladder disturbance, and mild diminution of lower extremity vibration sensation. It is classified as complicated if the impairment present in uncomplicated HSP is accompanied by other systemic or neurologic abnormalities such as ataxia, seizures, cognitive impairment, dementia, amyotrophy, extrapyramidal disturbance, or peripheral neuropathy. Diagnosis of HSP is based on clinical examination. There is no treatment to prevent or reverse nerve degeneration in HSP.