Hemangioma thrombocytopenia syndrome, called Kasabach-Merritt syndrome, is a very rare disorder characterized by profound thrombocytopenia in association with two rare vascular tumors: kaposiform hemangioendotheliomas and tufted angiomas. The occurance of profound thrombocytopenia can cause life-threatening bleeding and may progress to a disseminated coagulopathy in patients with these tumors.
Kasabach-Merritt syndrome typically occurs in early infancy or childhood, although prenatal cases, newborn presentations, and rare adult onset cases have been reported. Various treatments are used, with varying degrees of success including: systemic corticosteroids, radiation therapy, alpha 2a or 2b interferon therapy, vincristine administration, surgical excision, and an antiaggregant combination treatment with ticlopidine and aspirin.