The PDZD2 gene encodes a protein that contains six PDZ domains. However, proteolytic cleavage mediated by caspase results in a secreted peptide containing only two of these PDZ domains. While the function of PDZD2 is still not fully understood, it is known that PDZ domains frequently bind to the C-termini of transmembrane receptors or ion channels. Hence, it is speculated that the protein could be involved in intracellular signaling.
The gene is found to be upregulated in primary prostate tumors and evidence strongly suggests that accumulation of the protein may be associated with the initiation of prostate tumorigenesis. Recent studies have also shown a possible link between the gene and other cancers, particularly with gastric and renal cell carcinoma.