The DCLK2 gene encodes a protein belonging to the protein kinase superfamily.  While its protein kinase activity is carried out by its C-terminal serine/threonine protein kinase domain, its two N-terminal doublecortin domains bind microtubules and regulate their polymerization.  In between these two domains lies a serine/proline rich domain that is responsible for the mediation of several protein-protein interactions. 

Recent studies in humans have found a link between the DCLK2 gene and disorders such as epilepsy and ADHD. 

The 179 kb long DCLK2 gene is made up of 19 exons and is located on the long arm of chromosome 4.  The protein encoded by the gene is made up of 766 amino acids and is about 83 kDa in size.  Three slightly differing isoforms of the protein exist due to alternative splicing of the gene.  The DCLK2 gene is found to be expressed in the brain, heart and eyes.