Neu-Laxova syndrome is a severe disorder characterized by low plasma and CSF levels of serine and glycine. It results in severe intra-uterine growth retardation, microcephaly, seizures, ichthyotic skin, flexion deformities, limb malformations, and edema of the hands and feet. Patients usually suffer from facial dysmorphia, which may include a sloping forehead, micrognathia, low-set malformed ears, hypertelorism, absent or abnormal eyelids, a flat nose, a round gaping abnormal mouth, a high-arched or cleft palate, and a short neck. Brain anomalies such as decreased or absent gyri may also occur.