Tooth agenesis is a rare developmental dental anomaly in humans. It is characterized by the absence of six or more teeth, lack of development of maxillary and mandibular alveolar bone, problems in tooth eruption and exfoliation. Several forms of syndromic and non-syndromic oligodontia exist. STHAGX1 (Tooth Agenesis, Selective, X-Linked, 1) is a non-syndromic, heritable form of tooth agenesis. Non-syndromic tooth agenesis displays a broad phenotypic heterogeneity, even within the same family.
Diagnoses can be established through clinical examination and intra-oral X-ray. Treatment is given via a multidisciplinary team and is usually very costly. The simplest treatment involves minor prosthodontic interventions like a fixed partial denture.