The Potassium Channel, Voltage-Gated, Shaker-Related Subfamily, Member 2 (KCNA2) gene encodes a member of the voltage-gated potassium channel family that regulates neurotransmitter release, heart rate, neuronal excitability, smooth muscle contraction, epithelial electrolyte transport, insulin secretion, and cell volume. KCNA2 belongs to the KV1 subfamily of voltage‐gated potassium channels and can form functional homotetrameric and heterotetrameric channels with variable proportions of KCNA1, KCNA4, KCNA5, KCNA6, KCNA7, and other family members. These channels contribute towards the repolarization of the neuronal membrane following an action potential. They thus play a presynaptic role, prevent hyperexcitability and aberrant action potential firing, prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability, and play a significant role in motor coordination. Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury. Defects in this gene are the cause of infantile epileptic encephalopathy 32 (EIEE32), a condition characterized by refractory seizures, and neurodevelopmental impairment.