The ELMO2 gene encodes engulfment and cell motility protein 2. This protein interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Studies in mice models have shown that the ELMO2 protein may play a role in the regulation of cell proliferation and migration during the development of cerebral cortex.
Mutations in this gene have been known to cause an autosomal recessive condition called Vascular Malformation, Osseous (VMOS), characterized by localized lesions of arteriovenous, capillary, or lymphatic origin.