The PIP5K1A gene encodes a Phosphatidylinositol 4-phosphate 5-kinase that carries out the phosphorylation of phosphatidylinositol 4-phosphate to create phosphatidylinositol 4,5-bisphosphate. The enzyme localizes at nuclear speckles and forms a complex with TUT1, a poly(A) polymerase. This complex controls the expression of certain mRNAs such as cytoprotective enzymes and oxidative stress response genes. By carrying out its kinase activity, the PIP5K1A protein is also involved in several key biological processes such as phospholipid biosynthesis, actin cytoskeleton reorganization, cell chemotaxis and migration, signal transduction, phagocytosis and keratinocyte differentiation.