The PLK2 gene encodes a protein belonging to the polo family of serine/threonine protein kinases. Enzymes from this family function by phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. The PLK2 kinase is involved in several key biological processes such synaptic plasticity, memory formation, centriole replication, regulation of apoptosis and autophagy, Ras and Rap protein signal transduction and G1/S phase transition.