The MAMDC2 gene encodes a protein containing the MAM (mephrin, A5 antigen, protein tyrosine phosphatase mu) domain. It is found in the proteinaceous extracellular matrix as well as the endoplasmic reticulum. The human MAMDC2 protein is yet to be fully characterized and its function is currently unknown. However, mouse ortholog studies have found that the protein is involved in glycosaminoglycan binding.