The ARHGAP33 gene encodes a protein belonging to the sorting nexin family. Similar to other members of this family, the protein contains a phosphoinositide binding phox (PX) domain at its N terminal. The protein also contains SRC homology-3 (SH3) domain, a RHO GTPase-activating protein (GAP) domain, and 22 PxxP motifs in its proline- and serine-rich C-terminal domain. ARHGAP33 is speculated to have GTPase activator activity and is involved in small GTPase mediated signal transduction as well as protein transport. It is believed to play an important role in the regulation of insulin-stimulated glucose transport by acting as a downstream effector of RHOQ/TC10.