The AHNAK2 gene encodes a large nucleoprotein with a tripartite domain structure. Its relatively short N-terminal contains a PDZ domain, and is separated from the long C-terminal by a large body of repeats. The PDZ domain helps the AHNAK2 protein exist as a stable homodimer. While AHNAK2 has not yet been fully characterized, it is believed to associate with calcium channel proteins and play a role in calcium signaling.