Hypothyroidism is the most prevalent hormone deficiency caused by the production of insufficient amount of thyroid hormone. This may be due to failure of the thyroid gland to produce adequate amounts of hormone or failure of the pituitary gland to produce thyroid-stimulating hormone (TSH), or thyrotropin. In addition, hypothyroidism can result from the resistance to thyrotropin. Thyrotropin resistance hypothyroidism is a condition of thyroid refractoriness to TSH stimulation characterized by high levels of serum TSH, normal/reduced levels of serum thyroid hormone and a normal/hypoplastic thyroid gland. In general, hypothyroidism is more common among Whites and females than Africans and males, respectively.