Vitamin K-Dependent Clotting Factors, Combined Deficiency of, 1 (VKCFD) is an extremely rare congenital bleeding disorder resulting from decreased levels of coagulation factors II, VII, IX and X, as well as natural anticoagulants protein C, protein S and protein Z. Clinically, teh condition is characterized by mild to severe bleeding, with onset in the neonatal period.
VKCFD1 is caused by mutations in the GGCX gene. The protein product of the gene is involved in the post translational modification of proteins with calcium binding domains.