Interleukin 36 Receptor Antagonist

Alternative Names

IL36RN
Interleukin 1 Family, Member 5
IL1F5
Interleukin 1 Receptor Antagonist Homolog 1
IL1HY1
Family of Interleukin 1-Delta
FIL1-Delta
IL1RP3

Length

6,745 bases

No. of Exons

No. of isoforms

Protein Name

Interleukin-36 Receptor Antagonist protein

Molecular Mass

16962 Da

Amino Acid Count

155

Genomic Location

chr2:113,058,638-113,065,382

Gene Map Locus

2q14.1

Description

The IL36RN gene encodes a cytokine belonging to the interleukin 1 cytokine family. This protein inhibits the activity of interleukin-36 by binding to receptor IL1RL2. It is believed to play a role in mediating skin inflammation.

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_012275.2:c.338C>T	Lebanon	NC_000002.12:g.113062547C>T	Likely Pathogenic, Pathogenic, Uncertain Significance	Pathogenic	Psoriasis 14, Pustular	NG_031864.1:g.8910C>T; NM_012275.2:c.338C>T; NP_036407.1:p.Ser113Leu	144478519	30490

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External Links

https://ghr.nlm.nih.gov/gene/IL36RN

Contributors

Sayeeda Hana: 15.07.2019

Edit History

Sayeeda Hana: 15.07.2019

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