Forkhead Box N1

Alternative Names

  • FOXN1
  • Winged Helix Nude
  • WHN
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OMIM Number

600838

NCBI Gene ID

8456

Uniprot ID

O15353

Length

32,672 bases

No. of Exons

11

No. of isoforms

1

Protein Name

Forkhead Box Protein N1

Molecular Mass

68925 Da

Amino Acid Count

648

Genomic Location

chr17:28,506,229-28,538,900

Gene Map Locus
17q11.2

Description

The FOXN1 gene encodes a protein that functions as a transcription factor. It plays a vital role in the body's immune response as it is involved in the formation of the thymus gland and in maintaining T-cell homeostasis. It is also required for development of the epidermis, hair follicles and nails.  

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_003593.2:c.562delLebanonNC_000017.11:g.28524941delPathogenicT-Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy NG_007260.1:g.6001del; NM_003593.2:c.562del; NP_003584.2:p.Ser188AlafsTer1141597552140827573
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