Globally, IgA nephropathy is one of the leading causes of glomerulonephritis and end-stage renal disease. However, its pathogenesis remains unclear. The condition is characterised by hematuria and proteinuria, and about one-third of affected patients progress to renal failure.
Karnib et al. (2007), studied a large consanguineous Lebanese-Druze family with 16 affected individuals. Symptoms ranged from isolated hematuria to advanced renal failure. While an autosomal dominant inheritance was considered likely, the authors did not find evidence of linkage to known loci.