Epidermodysplasia Verruciformis, Susceptibility to, 2

Alternative Names

  • EV2
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WHO-ICD-10 version:2010

Endocrine, nutritional and metabolic diseases

Metabolic disorders

OMIM Number

618231

Mode of Inheritance

Autosomal recessive

Gene Map Locus

17q25.3

Description

Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with a high risk of skin cancer. EV results from an abnormal susceptibility to specific related human papillomavirus (HPV) genotypes and to the oncogenic potential of some of them, mainly HPV5. Infection with EV-associated HPV leads to the early development of disseminated flat wart-like and pityriasis versicolor-like lesions. Patients are unable to reject their lesions, and cutaneous Bowen carcinomas in situ and invasive squamous cell carcinomas develop in about half of them, mainly on sun-exposed areas. [From OMIM]

Epidemiology in the Arab World

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Subject IDCountrySexFamily HistoryParental ConsanguinityHPO TermsVariantZygosityMode of InheritanceReferenceRemarks
247100.9LebanonFemaleNoYes Papule; Skin plaque; Lichenoid skin le...NM_152468.5:c.917A>THeterozygous, HomozygousAutosomal, RecessiveO'Blenes et al. 2015
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