ADP-Ribosylation Factor-Like 11

Alternative Names

ARL11
ADP-Ribosylation Fcator-Like Tumor Suppressor
ARLTS1

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Length

5,417 bases

No. of Exons

No. of isoforms

Protein Name

ADP-ribosylation factor-like protein 11

Molecular Mass

21391 Da

Amino Acid Count

196

Genomic Location

chr13:49,628,456-49,633,872

Gene Map Locus

13q14.2

Description

This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [From RefSeq]

Epidemiology in the Arab World

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Lebanon

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_138450.6:c.446G>A	Lebanon	chr13:49630893	Benign	Uncertain Significance	Breast Cancer	NG_021342.1:g.7595G>A; NM_138450.6:c.446G>A ; NP_612459.1:p.Trp149Ter	34301344	769852
NM_138450.6:c.571G>A	Lebanon	chr13:49631018		Uncertain Significance	Breast Cancer	NG_021342.1:g.7720G>A; NM_138450.6:c.571G>A ; NP_612459.1:p.Gly191Arg	562619284

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ARL11 https://www.ncbi.nlm.nih.gov/gene/115761

Contributors

Pratibha Nair: 06.09.2020

Edit History

Pratibha Nair: 06.09.2020