DIS3-Like 3-Prime-5-Prime Exoribonuclease 2

Alternative Names

  • DIS3L2
  • DIS3 Mitotic Control, S. Cerevisiae, Homolog-Like 2
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OMIM Number

614184

NCBI Gene ID

129563

Uniprot ID

Q8IYB7

Length

383,106 bases

No. of Exons

21

No. of isoforms

5

Protein Name

DIS3-like exonuclease 2

Molecular Mass

99279 Da

Amino Acid Count

885

Genomic Location

chr2:231,961,245-232,344,350

Gene Map Locus
2q37.1

Description

The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_152383.5:c.1651_1652insGGGLebanonchr2:232263432-232263433Uncertain SignificanceBreast CancerNG_032572.1:g.306850_306851insGGG; NM_152383.5:c.1651_1652insGGG; NP_689596.4:p.Leu551delinsTrpVal
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