Lethal multiple pterygium syndrome (LMPS) is a rare inherited fetal-onset disorder. The anomalies of this condition involve the skin, muscles and skeleton. It is characterized by intrauterine growth retardation, multiple pterygia that present in multiple areas (chin to sternum, cervical, axillary, humero-ulnar, crural, popliteal, and the ankles) and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema varies from mild edematous skin to fetal hydrops with cystic hygroma, lung hypoplasia, and oligohydramnios. Facial anomalies include hypertelorism, epicanthal folds, flat nasal root, microretrognathism and microstomia, down-slanting palpebral fissures, low-set malformed ears, and cleft palate. Other anomalies include small chest, cryptorchidism, hypoplastic dermal ridges and creases, and more occasionally midforehead hemangioma, intestinal malrotation, cardiac hypoplasia, diaphragmatic hernia, obstructive uropathy, microcephaly, or cerebellar and pontine hypoplasia. Malignant hyperthermia was also described as a major complication before death.
