Weill-Marchesani syndrome (WMS) is a rare genetic disorder that is characterized by short stature, unusually short fingers (brachydactyly), joint stiffness, facial abnormalities, and eye abnormalities.
Homozygous mutations within the ADAMST10 gene (a disintegrin-like and metalloproteinase with thrombospondin type 1 motif, 10 gene) are found to be the cause of AR-WMS. ADAMTS10 plays a major role in human growth and the development of skin, lens, and heart.