Deafness, Autosomal Recessive 13

Alternative Names

  • DFNB13
Back to search Result
WHO-ICD-10 version:2010

Diseases of the ear and mastoid process

Other disorders of ear

OMIM Number

603098

Mode of Inheritance

Autosomal recessive

Gene Map Locus

7q34-q36

Description

Deafness (DFN), Autosomal Recessive (B) 13 (DFNB13) belongs to a large group of genetically heterogeneous hearing loss disorders. DFNB13 defines a genetic locus shown through linkage and fine mapping studies in multiple families to be inherited in individuals affected with moderate to profound sensorineural deafness. 

Epidemiology in the Arab World

View Map

Other Reports

Lebanon

Mustafa et al. (1998) studied autosomal recessive deafness in a large consanguineous Lebanese family with five siblings with nonsyndromic severe sensorineural deafness. Linkage studies mapped the genetic locus to 7q34q36 named DFNB13. 

Tunisia

Masmoudi et al. (2004) studied autosomal recessive deafness in two consanguineous Tunisian families with 11 members  with progressive nonsyndromic, severe to profound, bilateral sensorineural deafness. Linkage analysis and fine mapping narrowed the linkage interval described by Mustafa et al. (1998) in DFNB13 to a 2.2Mb interval which spanning 15 genes. 

© CAGS 2024. All rights reserved.