Deafness (DFN), Autosomal Recessive (B) 14 (DFNB14) belongs to a large group of genetically heterogeneous hearing loss disorders. DFNB14 defines a genetic locus shown through linkage and fine mapping studies in multiple families to be inherited in individuals affected with profound bilateral hearing loss.
Mustafa et al., 1998 studied autosomal recessive deafness in a large consanguineous Lebanese family. 4 individuals were described with nonsyndromic profound bilateral sensorineural deafness. Family linkage analysis identified a 15cM region between microsatellite marker D7S527 and the PDS gene to be responsible for the disorder.