The X- linked reticulate pigmentary disorder with systemic manifestations is a rare skin disorder characterized by a hyperpigmentation disorder of the skin. This disorder is mild in females showing brown pigmentation of the skin which follows the lines of Blaschko, while it is severe appearing as reticulate sheets in males. 

The reticulate pigmentary disorder with systemic manifestation is an X- linked disease which has been mapped to a locus in Xp22-p21.