Al-Awadi et al. (1985) reported three siblings (two females and a male) with primary hypogonadism and partial alopecia. Both sisters had hypoplastic internal genitalia and the brother showed results consistent with germinal cell aplasia. Their parents were consanguineous.

See: Jordan > Al-Awadi et al., 1985.

Megarbane et al. (2003) described two sisters from a consanguineous family with primary hypogonadism, partial alopecia and other associated symptoms. The clinical features observed in this study were comparable to those reported by Al-Awadi et al. (1985) and suggested the occurrence of a founder mutation for hypogonadism with alopecia in the Middle-Eastern population.