Al-Bustan et al. (2009) investigated the possible association of clinical variables and apolipoprotein (APOE, APOCI, and APOB) polymorphisms with the development of myocardial infarction (MI) and coronary heart disease (CHD) in Kuwaitis. APOCI genotype was determined by polymerase chain reaction followed by restriction fragment length polymorphism in 143 Kuwaiti CHD patients with (n = 88) and without (n = 55) MI and in 122 controls matched for gender and age. In this study, Al-Bustan et al. (2009) determined APOCI genotype by studying a polymorphism at the APOCI gene locus, an Hpa I restriction site, which has been described as an insertion of CGTT at 317 bp from the 5' transcription initiation site. A statistically significant association was found between CHD and medical history of diabetes mellitus (p < 0.001), hypertension (p < 0.01), high cholesterol (p < 0.05) and family history of CHD (p < 0.001). A highly significant association (p < 0.001) was found, with an adjusted odds ratio of 9.32, for family history and the development of MI. No significant differences were found for allele or genotype frequencies between CHD patients and controls. Al-Bustan et al. (2009) concluded that the strong effect of family history suggests a major genetic component for the development of CHD in Kuwaitis, but this association does not appear to be related to the APO genes investigated in this study. They also suggested that the results in this study encourage future research into these and other polymorphisms and their potential association with MI and CHD in the Kuwaiti population.