Monoamine Oxidase A

Alternative Names

  • MAOA
  • Amine Oxidase (Flavin-Containing) A

Associated Diseases

Brunner Syndrome
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OMIM Number

309850

NCBI Gene ID

4128

Uniprot ID

P21397

Length

91,918 bases

No. of Exons

16

No. of isoforms

2

Protein Name

Amine oxidase [flavin-containing] A

Molecular Mass

59682 Da

Amino Acid Count

527

Genomic Location

chrX:43,654,907-43,746,824

Gene Map Locus
Xp11.3

Description

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_000240.4:c.1078C>TLebanonchrX:43736254Likely PathogenicBrunner SyndromeNG_008957.2:g.85094C>T; NM_000240.4:c.1078C>T; NP_000231.1:p.Arg360Ter
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