JAZF Zinc Finger 1

Alternative Names

JAZF1
Juxtaposed With Another Zinc Finger Gene 1
TAK1-Interacting Protein 27
TIP27
JAZF1/JJAZ1 Fusion Gene, Included

Length

350,223 bases

No. of Exons

No. of isoforms

Protein Name

Juxtaposed with another zinc finger protein 1

Molecular Mass

27079 Da

Amino Acid Count

243

Genomic Location

chr7:27,830,572-28,180,794

Gene Map Locus

7p15.2-p15.1

Description

This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq]

Epidemiology in the Arab World

View Map

Variant Name	Country	Genomic Location	Clinvar Clinical Significance	CTGA Clinical Significance	Condition(s)	HGVS Expressions	dbSNP	Clinvar
NM_175061.3:c.115+39526A>G	United Arab Emirates	NC_000007.14:g.28140937T>C		Association	Type 2 Diabetes Mellitus	NG_011499.1:g.44882A>G; NM_175061.3:c.115+39526A>G; NP_778231.2:p.?	864745
NM_175061.3:c.115+39526A>T	Lebanon	NC_000007.14:g.28140937T>A		Benign		NG_011499.1:g.44882A>T; NM_175061.3:c.115+39526A>T; NP_778231.2:p.?	864745

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External Links

https://www.genecards.org/cgi-bin/carddisp.pl?gene=jazf1

Contributors

Asha Deepthi: 12.09.2021
Sami Bizzari: 11.03.2021

Edit History

Pratibha Nair: 09.02.2023
Asha Deepthi: 12.09.2021
Sami Bizzari: 11.03.2021

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