Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer, familial adenomatous polyposis, Peutz-Jeghers syndrome, Cowden disease, and the Li-Fraumeni syndrome. [From OMIM]
| Subject ID | Country | Sex | Family History | Parental Consanguinity | HPO Terms | Variant | Zygosity | Mode of Inheritance | Reference | Remarks |
|---|---|---|---|---|---|---|---|---|---|---|
| 613659.G.1.1 | Lebanon | Unknown | Neoplasm of the stomach Neoplasm of the stomach  | CYP2E1*6 Allele NM_000773.4:c.967+1143T>A, CYP1A1*2A Allele NG_061374.1:g.11229T>C | Heterozygous, Homozygous | Darazy et al. 2011 | 13 patients with gas... |
Radwan et al. 2018 reviewed 4 retrospective studies with data collected between 1982 and 2004. "The overall age-standardized cancer rates were 70.1 and 74.2 per 100,000 in males and females, respectively. Lung, gastric, and prostate cancer ranked as the top 3 types in Emirati males; while breast, cervical, and thyroid cancer were the top 3 types in Emirati females."