Nuclear Factor Erythroid 2-Like 3

Alternative Names

  • NFE2L3
  • NFE2-Related Factor 3
  • NRF3
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OMIM Number

604135

NCBI Gene ID

9603

Uniprot ID

Q9Y4A8

Length

34,940 bases

No. of Exons

4

No. of isoforms

1

Protein Name

Nuclear factor erythroid 2-related factor 3

Molecular Mass

76154 Da

Amino Acid Count

694

Genomic Location

chr7:26,152,197-26,187,136

Gene Map Locus
7p15.2

Description

This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NC_000007.14:g.25833490G>TUnited Arab EmiratesNC_000007.14:g.25833490G>TType 2 Diabetes Mellitus; Obesity10282436
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