Kruppel-Like Factor 11

Alternative Names

  • KLF11
  • Transforming Growth Factor-Beta-Inducible Early Growth Response 2
  • TIEG2
  • TGFB-Inducible Early Growth Response 2
  • Kruppel-Like Transcription Factor 1
  • FKLF1
  • FKLF
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OMIM Number

603301

NCBI Gene ID

8462

Uniprot ID

O14901

Length

11,287 bases

No. of Exons

6

No. of isoforms

2

Protein Name

Krueppel-like factor 11

Molecular Mass

55139 Da

Amino Acid Count

512

Genomic Location

chr2:10,043,549-10,054,835

Gene Map Locus
2p25.1

Description

The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NC_000002.12:g.10038352= United Arab EmiratesNC_000002.12:g.10038352=AssociationType 2 Diabetes Mellitus; Obesity3885668
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