B-Cell CLL/Lymphoma 2

Alternative Names

  • BCL2
  • Oncogene B-Cell Leukemia 2

Associated Diseases

Type 2 Diabetes Mellitus
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OMIM Number

151430

NCBI Gene ID

596

Uniprot ID

P10415

Length

196,935 bases

No. of Exons

6

No. of isoforms

2

Protein Name

Apoptosis regulator Bcl-2

Molecular Mass

26266 Da

Amino Acid Count

239

Genomic Location

chr18:63,123,345-63,320,279

Gene Map Locus
18q21.33

Description

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [From RefSeq]

Epidemiology in the Arab World

View Map
Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_000633.2:c.586-49892A>GUnited Arab EmiratesNC_000018.10:g.63178651T>CAssociationType 2 Diabetes MellitusNG_009361.1:g.145730A>G; NM_000633.2:c.586-49892A>G; NP_000624.2:p.?12454712
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