Melatonin Receptor 1B

Alternative Names

  • MTNR1B
  • MEL1B
  • MT2

Associated Diseases

Type 2 Diabetes Mellitus
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OMIM Number

600804

NCBI Gene ID

4544

Uniprot ID

P49286

Length

16,591 bases

No. of Exons

4

No. of isoforms

1

Protein Name

Melatonin receptor type 1B

Molecular Mass

40188 Da

Amino Acid Count

362

Genomic Location

chr11:92,969,650-92,986,240

Gene Map Locus
11q14.3

Description

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [From RefSeq]

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinvar Clinical SignificanceCTGA Clinical Significance Condition(s)HGVS ExpressionsdbSNPClinvar
NM_005959.3:c.223+5596C>GUnited Arab EmiratesNC_000011.10:g.92975544C>GAssociationType 2 Diabetes MellitusNG_028160.1:g.10922C>G; NM_005959.3:c.223+5596C>G; NP_005950.1:p.?10830963
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