607339.G.4

Country

Lebanon

HPO Terms

Coronary artery atherosclerosis

Subject Variants

Variant Name	Allele Count	Allele Frequency	Associated Disease	Associated Gene
CYP2E1*6 Allele NM_000773.4:c.967+1143T>A			Coronary Heart Disease, Susceptibility to, 1
CYP2E1*5B Allele NM_000773.3:c.[-1295G>C;-1055C>T]			Coronary Heart Disease, Susceptibility to, 1

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Remarks

Among 231 patients with morbid disease, 3 of 22 patients exhibited the CYP2E1*6 polymorphisms (and with CYP2E1*5B in addition, no. not specified). Significant decrease in association with coronary artery disease (p<0.019).

References

Zgheib et al. 2010