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Publications - Genetics Made Easy
Arab Genomic Studies
Blood Disorders

Authors: Ghazi Omar Tadmouri, Pratibha Nair, Tasneem Obeid, and Shirine Gallala

Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency: G6PD is an important element (enzyme) in the glucose oxidation (oxygen utilization) process of red blood cells and for maintaining their normal life span. G6PD deficiency is an inherited disorder caused by a defect or deficiency in the production of that enzyme. Consequently, G6PD deficiency may cause the destruction of RBCs leading to a condition known as hemolytic anemia in which the body cannot compensate for the destroyed cells...

Hemophilia: Hemophilia is the earliest known hereditary bleeding disorder. When injured, hemophiliacs tend to have a slow clotting (coagulation) process because of the lack of necessary blood factors (proteins). Consequently, those patients have prolonged bleeding after injury or surgery...

Sickle Cell Disease: All cells of the human body require a regular supply of oxygen to carry out their basic functions. Red blood cells (RBCs) are instrumental in carrying oxygen to the different parts of the body. This action is mediated by the help of a protein in the RBCs, called hemoglobin, which binds oxygen and transports it throughout the body...

Thalassemia: Thalassemia is an inherited blood related disorder due to absent or reduced production of hemoglobin, a protein present in red blood cells responsible for carrying oxygen through the body. Each red blood cell may contain between 240 and 300 million molecules of hemoglobin. A hemoglobin molecule has two sub-units commonly referred to as alpha and beta...

Thrombophilia: Blood contains many proteins regulating its substance. Some help keep it fluid to avoid blockage or strokes, while others help it to clot or thicken to stop bleeding in cases of wounds and cuts. Platelets are cellular fragments that play an important role in clot formation...