The LRP5 gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins. The Wnt signaling pathway is a series of steps that affect the way cells and tissues develop. It is important for cell division (proliferation), attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities.
The LRP5 protein plays an important role in the development of eye and inner ear, and formation of the bone, and is important for glucose and cholesterol metabolism.