Intercellular Adhesion Molecule 1

Alternative Names

  • ICAM1
  • CD54
  • Surface Antigen of Activated B Cells, BB2
  • BB2
  • Antigen Identified by Monoclonal Antibody BB2

Associated Diseases

Behçet Syndrome
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OMIM Number

147840

NCBI Gene ID

3383

Uniprot ID

P05362

Length

15,781

No. of Exons

7

No. of isoforms

1

Protein Name

Intercellular Adhesion Molecule 1

Molecular Mass

57825 Da

Amino Acid Count

532

Genomic Location

chr19:10,270,835-10,286,615

Gene Map Locus
19p13.2

Description

The ICAM1 gene encodes a a cell surface glycoprotein in the immunoglobulin superfamily. This protein binds to CD11a/CD18, or CD11b/CD18 integrins and it also acts as a cellular receptor for the Rhinovirus in case of infection. It plays a role in cell adhesion, signal transduction, and several malignancies.

Epidemiology in the Arab World

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Variant NameCountryGenomic LocationClinical SignificanceCondition(s)HGVS ExpressionsdbSNPClinvar
NM_000201.2:c.1405A>GJordan; Lebanon; Pales...chr19:10285007Risk factorBehçet SyndromeNG_012083.1:g.19167A>G; NM_000201.2:c.1405A>G; NP_000192.2:p.Lys469Glu5498
NM_000201.3:c.1099C>TLebanonNC_000019.10:g.10284576C>TUncertain SignificanceFamilial Mediterranean FeverNG_012083.1:g.18736C>T; NM_000201.3:c.1099C>T; NP_000192.2:p.Arg367Cys139178890

Other Reports

Qatar

Rizk and Derbala (2013) studied the association between ICAM 1 and IL28 polymorphisms and the viral clearance and the progression of hepatic fibrosis in HCV genotype 4 patients in Qatar. Thirty patients were included in the study. They were treated with pegylated interferon and ribavirin for 48 days. The patients were grouped to control group (responder) and case group (non-responder). Using the 5' nuclease assay with Fast Real-Time PCR System, three SNP's were genotyped; the rs5496 [A/G] and rs281437 [C/T] polymorphisms of the ICAM-1 gene and the rs12979860 [C/T] polymorphism of the IL-28B. No association was found between the rs5496 and rs281437 polymorphisms and the treatment response. However, patients who carried the T allele of the rs281437 polymorphism had approximately 13 times higher risk of severe fibrosis compared to patients with the C allele, while no association was found between the degree of fibrosis and the rs5496 polymorphism.

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