Pelizaeus-Merzbacher-like disease (PMLD) is an autosomal recessive hypomyelinating leukoencephalopathy disorder with a genetically heterogeneous pattern. It is virtually identical to Pelizaeus-Merzbacher disease (PMD) but without a mutation in the PLP1 gene that causes PMD. The prevalence is unknown, affecting males and females with equal frequency. PMLD is characterized by early-onset nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria, and progressive spasticity.
There is no standard treatment for individuals with Pelizaeus-Merzbacher like disease. Treatment is based upon specific symptoms present and supportive care.