Generalized Epilepsy with Febrile Seizures Plus, Type 7

Alternative Names

  • GEFSP7
  • GEFS+, Type 7
  • GEFS+7
  • Febrile Seizures, Familial, 3B
  • FEB3B
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WHO-ICD-10 version:2010

Diseases of the nervous system

Episodic and paroxysmal disorders

OMIM Number

613863

Gene Map Locus

2q24.3

Description

Generalized epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome in which family members display a seizure disorder from the GEFS+ spectrum which ranges from simple febrile seizures (FS) to the more severe phenotype of myoclonic-astatic epilepsy (MAE) or Dravet syndrome (DS). Mutations in the SCN9A gene cause a spectrum of seizure disorders, ranging from early-onset isolated febrile seizures to generalized epilepsy with febrile seizures plus, type 7, which represents a more severe phenotype. [From Orphanet and OMIM]

Epidemiology in the Arab World

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Subject IDCountrySexFamily HistoryParental ConsanguinityHPO TermsVariantZygosityMode of InheritanceReferenceRemarks
613863.1LebanonUnknownNo Seizure; Fever... NM_002977.3:c.4282G>AHeterozygousAutosomal, DominantJalkh et al. 2019
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